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KB-5492 free base

CAS No. 113594-64-2

KB-5492 free base( —— )

Catalog No. M35637 CAS No. 113594-64-2

KB-5492 free base is an orally available and selective antiulcer agent that inhibits sigma receptors, inhibits [3H]1,3-di(2-tolyl)guanidine (DTG) binding to sigma receptors, and may be useful in the study of gastric lesions and gastric secretion.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KB-5492 free base
  • Note
    Research use only, not for human use.
  • Brief Description
    KB-5492 free base is an orally available and selective antiulcer agent that inhibits sigma receptors, inhibits [3H]1,3-di(2-tolyl)guanidine (DTG) binding to sigma receptors, and may be useful in the study of gastric lesions and gastric secretion.
  • Description
    KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent.
  • In Vitro
    KB-5492 (0.001-100 μM) free base inhibits specific [3H]DTG binding in a concentration-dependent manner.KB-5492 (0.1-1 mM) free base significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells.
  • In Vivo
    KB-5492 (200?mg/kg; p.o.) free base prevents macroscopic lesions in the gastric mucosa.Animal Model:Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage Dosage:200?mg/kg Administration:Oral gavage Result:Reduced the lesion length as compared with the control.Prevented the deep mucosal lesions and exfoliation of surface epithelial cells.
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Sigma receptor
  • Recptor
    Sigma receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    113594-64-2
  • Formula Weight
    430.49
  • Molecular Formula
    C23H30N2O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (232.29 mM; Ultrasonic )
  • SMILES
    COc1ccc(OC(=O)CN2CCN(Cc3cc(OC)c(OC)c(OC)c3)CC2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Harada Y, et, al. Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain. Eur J Pharmacol. 1994 May 2; 256(3): 321-8.?
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